AdipoRon . hydrochloride (water soluble)

Overview
Catalog #	bs-75414c-10mg
Product Name	AdipoRon . hydrochloride (water soluble)
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 924416-43-3 (free base) Molecular formula: C27H28N2O3 . HCl . H2O Molecular weight: 428.5 . 36.5 . 18.0 Purity: >98% (HPLC, NMR) Appearance: White solid. Solubility: Highly soluble in DMSO (~50mg/ml). Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml). InChiKey: TZVJQEGKRLDTHQ-UHFFFAOYSA-N SMILES: [Cl-].O=C(COC1=CC=C(C=C1)C(=O)C1=CC=CC=C1)NC1CC[NH+](CC2=CC=CC=C2)CC1
Description	Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration [1, 2]. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells [1]. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism [1]. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms [1]. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet [1]. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice [1].