Bisindolylmaleimide IX . methansulfonate [Ro 31-8220]
| Overview | |
| Catalog # | bs-75400c-1mg |
| Product Name | Bisindolylmaleimide IX . methansulfonate [Ro 31-8220] |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Target | |
| Product Information | CAS Number: 138489-18-6 Molecular formula: C25H23N5O2S . CH4O3S Molecular weight: 457.6 . 96.1 Purity: >98% (NMR) Appearance: Red solid. Solubility: Soluble in DMSO. InChiKey: SAWVGDJBSPLRRB-UHFFFAOYSA-N SMILES: CS(O)(=O)=O.CN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CN(CCCSC(N)=N)C2=C1C=CC=C2 |
| Description | Selective and cell permeable protein kinase C (PKC) inhibitor [1, 2, 3]. Inhibits the stimulation of insulin secretion by glucose [4, 11]. Inhibits T cell activation [5]. Apoptosis inducer [6, 8, 9,10, 13]. Potent glycogen synthase kinase-3 (GSK-3) inhibitor [7]. Transcription inhibitor [9]. Induces TNF receptor family-mediated cell death [10]. Pim-1 kinase inhibitor [12]. Antitumor compound [13]. |
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