LY-294,002
| Overview | |
| Catalog # | bs-75397c-1mg |
| Product Name | LY-294,002 |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 154447-36-6 Molecular formula: C19H17NO3 Molecular weight: 307.4 Purity: >99% (NMR) Appearance: White to off-white crystalline solid. Solubility: Soluble in DMSO, 100% ethanol or methanol. InChiKey: CZQHHVNHHHRRDU-UHFFFAOYSA-N SMILES: O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCOCC1 |
| Description | Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4. |
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