LY-333,531 . hydrochloride
| Overview | |
| Catalog # | bs-75394c-1mg |
| Product Name | LY-333,531 . hydrochloride |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 1 year after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 169939-93-9 Molecular formula: C28H28N4O3 . HCl Molecular weight: 468.6 . 36.5 Purity: >98% (HPLC) Appearance: Red solid. Solubility: Soluble in DMSO. Slightly soluble in 100% ethanol or water. InChiKey: NYQIEYDJYFVLPO-FERBBOLQSA-N SMILES: Cl.CN(C)C[C@@H]1CCN2C=C(C3=C2C=CC=C3)C2=C(C(=O)NC2=O)C2=CN(CCO1)C1=C2C=CC=C1 |
| Description | Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta) [1, 6, 10, 11, 13]. PKCbetaI and PKCbetaII isozyme inhibitor [2-3, 6, 10, 11, 13]. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy [1, 3, 5-7, 9-11]. Anti-cancer and anti-angiogenic compound [4-5, 8]. Suppresses glucose-induced adhesion of human monocytes to endothelial cells [12]. Suppresses ERK1/2 and Akt phosphorylation [14]. |
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