SB203580

Overview
Catalog #	bs-75364c-1mg
Product Name	SB203580
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 152121-47-6 Molecular formula: C21H16FN3OS Molecular weight: 377.4 Purity: >99% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO or methanol. InChiKey: CDMGBJANTYXAIV-UHFFFAOYSA-N SMILES: C[S+]([O-])C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
Description	Cell permeable, specific p38 MAP kinase inhibitor [1, 2, 5]. Binds to the ATP binding site of p38 MAP kinase [3]. T cell proliferation inhibitor [4]. IL-2 production inhibitor [4]. SAPK/JNK inhibitor [5]. COX-1 and -2 inhibitor [6]. Raf-1 activator [7, 8]. Apoptosis enhancer [9]. Antiproliferative [10]. PDK1 inhibitor [10]. Anti-inflammatory [11]. Review [12]. Enhances cardiomyogenesis of human embryonic stem cells (hESCs) [13].