PD 184,352
| Overview | |
| Catalog # | bs-75363c-1mg |
| Product Name | PD 184,352 |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 212631-79-3 Molecular formula: C17H14ClF2IN2O2 Molecular weight: 478.7 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO. InChiKey: GFMMXOIFOQCCGU-UHFFFAOYSA-N SMILES: FC1=C(F)C(NC2=CC=C(I)C=C2Cl)=C(C=C1)C(=O)NOCC1CC1 |
| Description | MEK (MAPKK) inhibitor [5]. Potent and selective MAPK (ERK kinase 1; MEK1) activation inhibitor (IC50 = 300 nM in vitro, IC50 = 2 nM in vivo) [1, 2]. Suppresses activation of MAPK but does not block its activity [3]. Antiproliferative [4]. Causes cell-cycle arrest in G1 phase [4]. Tumor suppressor [1, 5]. Apoptosis inducer [6]. |
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