1400W . dihydrochloride

Overview
Catalog #	bs-75352c-5mg
Product Name	1400W . dihydrochloride
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at +4°C.
Target
Product Information	CAS Number: 214358-33-5 Molecular formula: C10H15N3 . 2HCl Molecular weight: 177.3 . 72.9 Purity: >98% (NMR) Appearance: White to off-white solid. Solubility: Soluble in water, methanol or DMSO. InChiKey: WDJHSQZCZGPGAA-UHFFFAOYSA-N SMILES: [Cl-].[Cl-].CC(=N)[NH2+]CC1=CC=CC(C[NH3+])=C1
Description	A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd < 7 nM) [1, 3, 4, 6]. Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki < 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki < 50 µM) [1]. Inhibits tumor growth [2]. Increases vasoconstriction to noradrenaline [7]. Improves contractile function [8]. Improves stroke outcome and decreases glutamate release [9]. Anti-inflammatory [10]. Significant AMPK activity suppressor. Review [5].