Boc-Asp(OMe)-FMK

Overview
Catalog #	bs-75313c-1mg
Product Name	Boc-Asp(OMe)-FMK
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 3 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 187389-53-3 Molecular formula: C11H18FNO5 Molecular weight: 263.3 Purity: >98% Appearance: White to off-white powder. Solubility: Soluble in ethanol (5mg/ml), DMSO or DMF (both 30mg/ml). InChiKey: IPYYWMLWOBWDDP-UHFFFAOYSA-N SMILES: FCC([C@@H](NC(OC(C)(C)C)=O)C(OC)=O)=O
Description	Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha (IC50=39µM). Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.