MOTS-c (human)
Overview | |
Catalog # | bs-75310c-1mg |
Product Name | MOTS-c (human) |
Specifications | |
Storage Buffer | Powder |
Storage Condition | Stable for 1 year after receipt when stored at -20°C. |
Target | |
Product Information | CAS Number: 1627580-64-6 Molecular formula: C101H152N28O22S2 . C2HF3O2 Molecular weight: 2174.6 . 114.0 Purity: >95% (HPLC) Appearance: White lyophilized powder. Solubility: Soluble in water. InChiKey: JLKDYZLVBJDJTO-DNWXONKHSA-N SMILES: OC(=O)C(F)(F)F.[H]N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
Description | Mitochondria-derived peptide (MDP). Promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase (AMPK). Induces cellular and systemic glucose uptake and improves insulin sensitivity. Shown to prevent diet-induced obesity (DIO) in mice. Potential anti-obesity and anti-aging compound. Involved in cellular stress resistance by regulating the nuclear genome. During metabolic stress (serum or glucose deprivation or oxidative stress) translocates to the nucleus in an AMPK-dependent manner. In the nucleus, MOTS-c binds to the transcription factor NRF2 that is a stress-responsive transcription factor and activates anti-oxidative stress genes. |