Q-VD-OPh
Overview | |
Catalog # | bs-75292c-1mg |
Product Name | Q-VD-OPh |
Specifications | |
Storage Buffer | Solid |
Storage Condition | Stable for 3 years after receipt when stored at -20°C. |
Target | |
Product Information | CAS Number: 1135695-98-5 (anhydrous) Molecular formula: C26H25F2N3O6 Molecular weight: 513.5 Purity: >95% (TLC) Appearance: White solid. Solubility: Soluble in DMSO. InChiKey: OOBJCYKITXPCNS-AKRCKQFNSA-N SMILES: CC(C)[C@H](NC(=O)C1=CC=C2C=CC=CC2=N1)C(=O)NC(CC(O)=O)C(=O)COC1=C(F)C=CC=C1F |
Description | Cell permeable, irreversible and non-toxic non-FMK pan-caspase inhibitor with improved potency, stability and toxicity over Z-VAD-FMK. Does not cross-react with cathepsins nor calpains. Non-toxic due to the 2,6-difluorophenoxy methyl (OPh) group. The peptide is not O-methylated to reduce hydrophobicity and to facilitate use in aqueous media. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Used in apoptosis and inflammasome studies. |