Phomopsin A

Overview
Catalog #	bs-75265c-1mg
Product Name	Phomopsin A
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 64925-80-0 Molecular formula: C36H45ClN6O12 Molecular weight: 789.2 Purity: >98% (HPLC, TLC) Appearance: White solid. Solubility: Soluble in DMSO (10mg/ml), ethanol, methanol (5mg/ml) or DMF. InChiKey: FAFRRYBYQKPKSY-KBIMZEDXSA-N SMILES: ClC1=CC([C@H](O)[C@@H]2NC)=CC(O[C@@](C)(CC)[C@H](C(N3CC=C[C@H]3C(N/C(C(N/C(C(O)=O)=C/C(O)=O)=O)=C(C)/CC)=O)=O)NC([C@H](C(C)=C)NC2=O)=O)=C1O
Description	Macrocyclic heptapeptide mycotoxin. Potent anti-mitotic compound that can cause cell death. Microtubule assembly inhibitor. Binds selectively to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Binds at a site different from the colchicine binding site and overlapping the vinblastine binding site. Inhibits tubulin-dependent GTP hydrolysis. Binds beta-tubulin from higher organisms but not alpha-tubulin or fungal mycelial tubulin. Causes lupinosis (a degenerative disorder) in livestock fed infected lupins.