Forskolin

Overview
Catalog #	bs-75078c-1mg
Product Name	Forskolin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 66428-89-5 and 66575-29-9 Molecular formula: C22H34O7 Molecular weight: 410.5 Purity: >99% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in ethyl acetate, anhydrous DMSO or ethanol; very poorly soluble in water. DMSO is the recommended solvent for activation of cAMP. InChiKey: OHCQJHSOBUTRHG-KGGHGJDLSA-N SMILES: [H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]1(C)[C@@H](O)CCC2(C)C)C=C
Description	Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels [1, 2, 6]. Widely used tool to investigate cAMP as a second messenger [15]. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator [3, 4, 6]. Glucose transporter inhibitor [4]. Platelet aggregation inhibitor [3, 10]. Stimulates lipolysis in fat cells [8]. Non-competitive nicotinic acetylcholine receptors inhibitor [9]. MAP kinase inhibitor [11]. Upregulates mitochondrial uncoupling protein (UCP) mRNA levels in brown adipose tissue [12]. Autophagy inhibitor [13]. Hedgehog signaling inhibitor [14]. Has antiglaucoma potential [16]. Promotes neuronal differentiation of NSCs [17]. Anti-neuroinflammatory and neuroprotective agent. Ameliorated Alzheimer’s disease symptoms, restoring impairment in nesting ability and sociability, and reducing neuroinflammation and amyloid beta deposition [18].