Apicidin

Overview
Catalog #	bs-75077c-1mg
Product Name	Apicidin
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 1 year after receipt when stored at -20°C. Stock solutions are stable for 3 months when stored at -20°C.
Target
Product Information	CAS Number: 183506-66-3 Molecular formula: C34H49N5O6 Molecular weight: 623.8 Purity: >98% (HPLC, TLC) Appearance: White to off-white solid. Solubility: Soluble in ethanol or DMSO. InChiKey: JWOGUUIOCYMBPV-LQJYRIKDSA-N SMILES: [H][C@]12CCCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CC1=CN(OC)C3=C1C=CC=C3)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC
Description	Antiprotozoal [1]. Potent inhibitor of histone deacetylase (HDAC) [1,2]. Inhibits proliferation [2,3]. Induces cell cycle arrest at the G1 phase [2]. Induces hyperacetylation of histone H4 [5]. Apoptosis inducer [4,8,9]. Potent anti-angiogenic compound [5-7]. Decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines [3]. Autophagy inducer in oral squamous cell carcinoma (OSCC) cells [8]. Promotes either self-renewal or differentiation of embryonic stem cells [10].