Cyclopamine
Overview | |
Catalog # | bs-75029c-1mg |
Product Name | Cyclopamine |
Specifications | |
Storage Buffer | Solid |
Storage Condition | Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
Target | |
Product Information | CAS Number: 4449-51-8 Molecular formula: C27H41NO2 Molecular weight: 411.6 Purity: >98% Appearance: White to off-white solid. Solubility: Soluble in ethanol, methanol, DMF or DMSO. Insoluble in water. InChiKey: QASFUMOKHFSJGL-LAFRSMQTSA-N SMILES: [H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]1(CC[C@]3([H])C(C[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)O2 |
Description | Cell permeable steroidal alkaloid. Specific sonic hedgehog (Shh) signaling pathway inhibitor. Directly interacts/inhibits Smo (smoothened) [1-4]. Teratogenic [1] and antitumor compound. Inhibits tumor cell growth and progression. Shows selective activity against Shh-dependent tumors [5-11]. Blocks abnormal cell growth associated with oncogenic mutations of Ptch and Smo in fibroblasts [2]. Arrests cell cycle at G0/G1 [6]. Apoptosis inducer [8]. |