Apilimod dimesylate

Overview
Catalog #	bs-7180c-2mg-solid
Product Name	Apilimod dimesylate
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 610.7 Formula: C25 H34 N6 O8 S2 CAS Number: 870087-36-8 InChi Key: GAJWNIKZLYZYSY-OKUPSQOASA-N InChi: InChI=1S/C23H26N6O2.2CH4O3S/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20;21-5(2,3)4/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28);21H3,(H,2,3,4)/b25-17+;; Smiles: CC1C=C(C=CC=1)/C=N/NC1=CC(=NC(=N1)OCCC1C=CC=CN=1)N1CCOCC1.CS(O)(=O)=O.CS(O)(=O)=O Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	Apilimod dimesylate, also known as STA-5326, is a IL-12/IL-23 inhibitor. Apilimod inhibits IL-12 and IL-23 production - cytokines that are involved in autoimmune diseases - through the prevention of nuclear translocation of c-Rel. Synta Pharmaceuticals Corp is developing apilimod for the potential treatment of Crohn's disease (CD) and other autoimmune diseases. Preclinical studies demonstrated the successful inhibition of IL-12 and IL-23 production by the drug.