CRBN PROTAC 14a

Overview
Catalog #	bs-7160c-10mg-solid
Product Name	CRBN PROTAC 14a
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 1061.25 Formula: C53 H72 N8 O13 S CAS Number: 2358775-70-7 InChi Key: PEZCAXDTKNFUCR-CTMFSBKBSA-N InChi: InChI=1S/C53H72N8O13S/c1-34-46(75-33-57-34)36-16-14-35(15-17-36)29-56-48(66)41-28-37(62)30-60(41)52(70)47(53(2,3)4)58-44(65)32-74-25-10-6-8-23-72-27-26-71-22-7-5-9-24-73-31-43(64)55-21-20-54-39-13-11-12-38-45(39)51(69)61(50(38)68)40-18-19-42(63)59-49(40)67/h11-17,33,37,40-41,47,54,62H,5-10,18-32H2,1-4H3,(H,55,64)(H,56,66)(H,58,65)(H,59,63,67)/t37-,40?,41+,47-/m1/s1 Smiles: CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCCOCCOCCCCCOCC(=O)NCCNC2C=CC=C3C=2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)=CC=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	CRBN PROTAC® 14a is a cereblon degrader. It comprises a ligand for Von Hippel Lindau (VHL) protein joined by a linker to a cereblon targeting ligand. It preferentially degrades cereblon, and induces rapid and profound cereblon degradation.