3PO

Overview
Catalog #	bs-7135c-2mg-solid
Product Name	3PO
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 210.23 Formula: C13 H10 N2 O CAS Number: 18550-98-6 InChi Key: UOWGYMNWMDNSTL-ONEGZZNKSA-N InChi: InChI=1S/C13H10N2O/c16-13(12-5-8-14-9-6-12)4-3-11-2-1-7-15-10-11/h1-10H/b4-3+ Smiles: O=C(C=CC1C=NC=CC=1)C1C=CN=CC=1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor. 3PO reduces glycolytic flux and suppresses glucose uptake. 3PO may be useful agents in combination with other drugs that inhibit cancer cell proliferation. PFKFB3 inhibitors suppress glucose uptake, which in turn causes an increase in autophagy. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer. Note: this product has been assigned 2 CAS#: 18550-98-6 and 13309-08-5,