A66

Overview
Catalog #	bs-7134c-2mg-solid
Product Name	A66
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 393.53 Formula: C17 H23 N5 O2 S2 CAS Number: 1166227-08-2 InChi Key: HBPXWEPKNBHKAX-NSHDSACASA-N InChi: InChI=1S/C17H23N5O2S2/c1-9-12(10-8-25-14(20-10)17(2,3)4)26-15(19-9)21-16(24)22-7-5-6-11(22)13(18)23/h8,11H,5-7H2,1-4H3,(H2,18,23)(H,19,21,24)/t11-/m0/s1 Smiles: CC1N=C(NC(=O)N2CCC[C@H]2C(N)=O)SC=1C1=CSC(=N1)C(C)(C)C Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	A66 is a potent and highly selective p110α inhibitor with IC50 of 32 nM in a cell-free assay, >100 fold selectivity for p110α over other class-I PI3K isoforms. A66 blocks phosphoinositide 3-kinase signalling and tumour growth in certain cell types.