Azeliragon HCl

Overview
Catalog #	bs-7100c-10mg-solid
Product Name	Azeliragon HCl
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 605.04 Formula: C32 H40 Cl3 N3 O2 CAS Number: 1284150-65-7 InChi Key: CQAGJWKITXAOAM-UHFFFAOYSA-N InChi: InChI=1S/C32H38ClN3O2.2ClH/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29;;/h10-21,24H,4-9,22-23H2,1-3H3;2*1H Smiles: Cl.Cl.CCCCC1=NC(=CN1C1C=CC(=CC=1)OC1C=CC(Cl)=CC=1)C1C=CC(=CC=1)OCCCN(CC)CC Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	Azeliragon free base, also known as TTP488 and PF-04494700, is a potent and orally active RAGE inhibitor. RAGE (receptor for advanced glycation endproducts) is a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon is a promising agent for for Alzheimer's disease and cerebral amyloid angiopathy.