Ro 08-2750

Overview
Catalog #	bs-7061c-10mg-solid
Product Name	Ro 08-2750
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 270.24 Formula: C13 H10 N4 O3 CAS Number: 37854-59-4 InChi Key: JDEMVNYMYPJJIM-UHFFFAOYSA-N InChi: InChI=1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20) Smiles: CC1=CC2N=C3C(=NC(=O)NC3=O)N(C)C=2C=C1C=O Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM). NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief.