Pilaralisib

Overview
Catalog #	bs-7038c-10mg-solid
Product Name	Pilaralisib
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 541.02 Formula: C25 H25 Cl N6 O4 S CAS Number: 934526-89-3 InChi Key: QINPEPAQOBZPOF-UHFFFAOYSA-N InChi: InChI=1S/C25H25ClN6O4S/c1-25(2,27)24(33)28-15-7-6-8-17(13-15)37(34,35)32-23-22(29-19-9-4-5-10-20(19)30-23)31-21-14-16(36-3)11-12-18(21)26/h4-14H,27H2,1-3H3,(H,28,33)(H,29,31)(H,30,32) Smiles: CC(C)(N)C(=O)NC1C=C(C=CC=1)S(=O)(=O)NC1=NC2=CC=CC=C2N=C1NC1C=C(C=CC=1Cl)OC Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	Pilaralisib, also known as XL147, is a Class 1 PI3K kinase family inhibitor with potential antineoplastic activity. XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis.