Brigatinib-analog

Overview
Catalog #	bs-7035c-10mg-solid
Product Name	Brigatinib-analog
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 529.01 Formula: C26 H34 Cl N6 O2 P CAS Number: 1197958-12-5 InChi Key: OVDSPTSBIQCAIN-UHFFFAOYSA-N InChi: InChI=1S/C26H34ClN6O2P/c1-32(2)18-12-14-33(15-13-18)19-10-11-21(23(16-19)35-3)30-26-28-17-20(27)25(31-26)29-22-8-6-7-9-24(22)36(4,5)34/h6-11,16-18H,12-15H2,1-5H3,(H2,28,29,30,31) Smiles: CN(C)C1CCN(CC1)C1=CC(OC)=C(C=C1)NC1N=C(NC2C=CC=CC=2P(C)(C)=O)C(Cl)=CN=1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	Brigatinib-analog is an orally active, potent and selective anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) inhibitor. Brigatinib-analog is structurally related to Brigatinib (AP-26113). Brigatinib-analog binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. This leads to the inhibition of ALK kinase and EGFR kinase, disrupts their signaling pathways and eventually inhibits tumor cell growth in susceptible tumor cells.