Selonsertib free base
| Overview | |
| Catalog # | bs-7001c-10mg-solid |
| Product Name | Selonsertib free base |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 445.49 Formula: C24 H24 F N7 O CAS Number: 1448428-04-3 InChi Key: YIDDLAAKOYYGJG-UHFFFAOYSA-N InChi: InChI=1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,28,29,33) Smiles: CC1=CC(F)=C(C=C1N1C=C(N=C1)C1CC1)C(=O)NC1C=CC=C(N=1)C1=NN=CN1C(C)C Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. |
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