APX-115 free base
| Overview | |
| Catalog # | bs-6995c-10mg-solid |
| Product Name | APX-115 free base |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 279.34 Formula: C17 H17 N3 O CAS Number: 1270084-92-8 InChi Key: LQKQLKMTJOMCMJ-UHFFFAOYSA-N InChi: InChI=1S/C17H17N3O/c1-2-8-14-16(13-9-4-3-5-10-13)19-20(17(14)21)15-11-6-7-12-18-15/h3-7,9-12,21H,2,8H2,1H3 Smiles: CCCC1C(=NN(C=1O)C1C=CC=CN=1)C1C=CC=CC=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | APX-115, also known as EWHA-18278, is a potent, orally active pan NADPH oxidase (Nox) inhibitor. APX-115 protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice. APX-115 might be a promising therapeutic agent for the treatment of DN because of its pan-NOX inhibitory activity, including its NOX5 inhibitory activity, and also owing to its anti-inflammatory effect. |
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