NE 52-QQ57

Overview
Catalog #	bs-6978c-10mg-solid
Product Name	NE 52-QQ57
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 416.52 Formula: C24 H28 N6 O CAS Number: 1401728-56-0 InChi Key: HXPQWNPLNIEJOW-UHFFFAOYSA-N InChi: InChI=1S/C24H28N6O/c1-4-21-20(22-26-15(2)13-16(3)30(22)29-21)14-17-5-7-18(8-6-17)23-27-28-24(31-23)19-9-11-25-12-10-19/h5-8,13,19,25H,4,9-12,14H2,1-3H3 Smiles: CCC1=NN2C(N=C(C)C=C2C)=C1CC1C=CC(=CC=1)C1=NN=C(O1)C1CCNCC1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	NE52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).