Sardomozide HCl

Overview
Catalog #	bs-6965c-10mg-solid
Product Name	Sardomozide HCl
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 303.19 Formula: C11 H16 Cl2 N6 CAS Number: 138794-73-7 InChi Key: UHEIPGJSFDAPIC-NENXIMLWSA-N InChi: InChI=1S/C11H14N6.2ClH/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15;;/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17);2*1H/b16-9+;; Smiles: Cl.Cl.[H]/N=C(\N)/NN=C1CCC2C1=CC=CC=2C(N)=N Purity: 98.0 Solubility: Soluble in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	Sardomozide HCl, also known as SAM486A or CGP48664, is a second-generation polyamine synthesis inhibitor, which inhibits the activity of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC). SAM486 is more potent and specific than the first-generation SAMDC inhibitor methylglyoxal (bis) guanylhydrazone (MGBG). Preclinical testing confirmed promising antiproliferative activity. The in vitro tests showed that p53 wild-type NB cells were highly sensitive to SAM486A treatment. Most notably, SAM486A treatment resulted in the rapid accumulation of proapoptotic proteins p53 and Mdm2.