SIS3 HCl

Overview
Catalog #	bs-6876c-10mg-solid
Product Name	SIS3 HCl
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 489.99 Formula: C28 H28 Cl N3 O3 CAS Number: 521984-48-5 InChi Key: CDKIEBFIMCSCBB-CALJPSDSSA-N InChi: InChI=1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+; Smiles: Cl.CN1C(=C(/C=C/C(=O)N2CC3=CC(OC)=C(C=C3CC2)OC)C2C=CC=NC1=2)C1C=CC=CC=1 Purity: 98.0 Solubility: DMSO : ≥ 30 mg/mL (61.23 mM) Appearance: Solid Power. Shelf Life: 1.0 years
Description	SIS3 HCl, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.