CCG-222740

Overview
Catalog #	bs-6865c-10mg-solid
Product Name	CCG-222740
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 444.86 Formula: C23 H19 Cl F2 N2 O3 CAS Number: 1922098-69-8 InChi Key: PMTPYUTZAJWGPE-UHFFFAOYSA-N InChi: InChI=1S/C23H19ClF2N2O3/c24-18-6-8-19(9-7-18)27-21(29)17-12-23(25,26)14-28(13-17)22(30)16-4-1-3-15(11-16)20-5-2-10-31-20/h1-11,17H,12-14H2,(H,27,29) Smiles: O=C(C1=CC(=CC=C1)C1=CC=CO1)N1CC(CC(F)(F)C1)C(=O)NC1C=CC(Cl)=CC=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	CCG-222740 is a potent MRTF/SRF inhibitor. CCG-222740 markedly decreased SRF reporter gene activity and showed a greater inhibitory effect on MRTF/SRF target genes than the previously described MRTF-A inhibitor CCG-203971. CCG-222740 was also five times more potent, with an IC50 of 5 μM, in a fibroblast-mediated collagen contraction assay, was less cytotoxic, and a more potent inhibitor of alpha-smooth muscle actin protein expression than CCG-203971.