N-Desmethyltamoxifen hydrochloride

Overview
Catalog #	bs-6815c-10mg-solid
Product Name	N-Desmethyltamoxifen hydrochloride
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 393.95 Formula: C25 H28 Cl N O CAS Number: 15917-65-4 InChi Key: GMLHJWZEYLTNJW-BJFQDICYSA-N InChi: InChI=1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-; Smiles: Cl.CC/C(=C(\C1C=CC=CC=1)/C1C=CC(=CC=1)OCCNC)/C1C=CC=CC=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.