Afuresertib

Overview
Catalog #	bs-6803c-10mg-solid
Product Name	Afuresertib
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 427.32 Formula: C18 H17 Cl2 F N4 O S CAS Number: 1047644-62-1 InChi Key: AFJRDFWMXUECEW-LBPRGKRZSA-N InChi: InChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1 Smiles: CN1N=CC(Cl)=C1C1C=C(SC=1Cl)C(=O)N[C@H](CN)CC1=CC(F)=CC=C1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	Afuresertib, also known as GSK-2110183 or GSK-2110183C, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis