Ruboxistaurin hydrochloride

Overview
Catalog #	bs-6795c-10mg-solid
Product Name	Ruboxistaurin hydrochloride
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 505.01 Formula: C28 H29 Cl N4 O3 CAS Number: 169939-93-9 InChi Key: NYQIEYDJYFVLPO-FERBBOLQSA-N InChi: InChI=1S/C28H28N4O3.ClH/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24;/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34);1H/t18-;/m0./s1 Smiles: Cl.CN(C)C[C@@H]1CCN2C=C(C3=C(C4=CN(CCO1)C1=CC=CC=C14)C(=O)NC3=O)C1=CC=CC=C21 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	Ruboxistaurin hydrochloride, also known as LY-333531 hydrochloride, is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.