AF-353

Overview
Catalog #	bs-6717c-10mg-solid
Product Name	AF-353
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 400.21 Formula: C14 H17 I N4 O2 CAS Number: 865305-30-2 InChi Key: AATPYXMXFBBKFO-UHFFFAOYSA-N InChi: InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19) Smiles: COC1=CC(C(C)C)=C(C=C1I)OC1=CN=C(N)N=C1N Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	AF-353 is a P2X3 receptor antagonist. Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system.