PTC-028

Overview
Catalog #	bs-6716c-10mg-solid
Product Name	PTC-028
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 405.32 Formula: C19 H12 F5 N5 CAS Number: 1782970-28-8 InChi Key: JEZGPBWIZWPDHP-UHFFFAOYSA-N InChi: InChI=1S/C19H12F5N5/c1-10-26-15-6-13(20)14(21)7-16(15)29(10)18-9-25-8-17(28-18)27-12-4-2-11(3-5-12)19(22,23)24/h2-9H,1H3,(H,27,28) Smiles: CC1=NC2=CC(F)=C(F)C=C2N1C1C=NC=C(NC2C=CC(=CC=2)C(F)(F)F)N=1 Purity: 98.0 Solubility: DMSO: 81 mg/mL(199.84 mM). Appearance: Solid Power. Shelf Life: 1.0 years
Description	PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification. In vivo, orally administered PTC-028, as a single agent, exhibits significant antitumor activity comparable with the standard cisplatin/paclitaxel therapy in an orthotopic mouse model of ovarian cancer.