TAS-116

Overview
Catalog #	bs-6713c-10mg-solid
Product Name	TAS-116
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 454.53 Formula: C25 H26 N8 O CAS Number: 1260533-36-5 InChi Key: JMNDKGSFCHWKBP-UHFFFAOYSA-N InChi: InChI=1S/C25H26N8O/c1-5-26-25(34)17-6-8-19(9-7-17)33-24-22(23(30-33)16(2)3)21(10-11-27-24)32-14-20(28-15-32)18-12-29-31(4)13-18/h6-16H,5H2,1-4H3,(H,26,34) Smiles: CN1C=C(C=N1)C1=CN(C=N1)C1C=CN=C2C=1C(=NN2C1C=CC(=CC=1)C(=O)NCC)C(C)C Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	TAS-116, also known as Pimitespib, is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo/radiosensitizing activities. TAS-116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent-signaling, induces apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta.