ROC-325

Overview
Catalog #	bs-6701c-10mg-solid
Product Name	ROC-325
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 503.06 Formula: C28 H27 Cl N4 O S CAS Number: 1859141-26-6 InChi Key: HXUYKEGAEIYPKY-UHFFFAOYSA-N InChi: InChI=1S/C28H27ClN4OS/c1-18-7-10-23(26-27(34)21-5-3-4-6-25(21)35-28(18)26)32-14-16-33(2)15-13-31-22-11-12-30-24-17-19(29)8-9-20(22)24/h3-12,17,32H,13-16H2,1-2H3,(H,30,31) Smiles: CC1=CC=C(NCCN(C)CCNC2=CC=NC3=CC(Cl)=CC=C23)C2=C1SC1=CC=CC=C1C2=O Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power. Shelf Life: 1.0 years
Description	ROC-325 is an autophagy inhibitor. ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. ROC-325 antagonized RCC growth and survival in an ATG5/7-dependent manner, induced apoptosis, and exhibited favorable selectivity.