Dabrafenib

Overview
Catalog #	bs-6667c-10mg-solid
Product Name	Dabrafenib
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 519.56 Formula: C23 H20 F3 N5 O2 S2 CAS Number: 1195765-45-7 InChi Key: BFSMGDJOXZAERB-UHFFFAOYSA-N InChi: InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) Smiles: CC(C)(C)C1=NC(=C(S1)C1C=CN=C(N)N=1)C1=CC=CC(NS(=O)(=O)C2C(F)=CC=CC=2F)=C1F Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	Dabrafenib, also known as GSK2118436 , is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. On May 29, 2013, FDA approved this drug.