KM 11060

Overview
Catalog #	bs-6624c-10mg-solid
Product Name	KM 11060
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 422.33 Formula: C19 H17 Cl2 N3 O2 S CAS Number: 774549-97-2 InChi Key: GIEHIZKCIZLXLF-UHFFFAOYSA-N InChi: InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2 Smiles: O=S(=O)(C1C=CC(Cl)=CC=1)N1CCN(CC1)C1=CC=NC2=CC(Cl)=CC=C12 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.