AL 082D06

Overview
Catalog #	bs-6619c-10mg-solid
Product Name	AL 082D06
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 409.91 Formula: C23 H24 Cl N3 O2 CAS Number: 256925-03-8 InChi Key: IPICUXHYPAMJNC-UHFFFAOYSA-N InChi: InChI=1S/C23H24ClN3O2/c1-25(2)18-9-5-16(6-10-18)23(17-7-11-19(12-8-17)26(3)4)21-15-20(27(28)29)13-14-22(21)24/h5-15,23H,1-4H3 Smiles: CN(C)C1C=CC(=CC=1)C(C1C=C(C=CC=1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)C Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years
Description	AL082D06, also known as D-06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid-mediated transcriptional regulation. AL082D06 binds competitively with steroids, likely occupying a similar site within the ligand-binding domain.