TG6-10-1
| Overview | |
| Catalog # | bs-6610c-10mg-solid |
| Product Name | TG6-10-1 |
| Specifications | |
| Storage Buffer | Powder |
| Storage Condition | Store in dry, dark place at -20C for 1 year. |
| Target | |
| Product Information | Molecular Weight: 448.43 Formula: C23 H23 F3 N2 O4 CAS Number: 1415716-58-3 InChi Key: WUYOECAJFJFUFC-CMDGGOBGSA-N InChi: InChI=1S/C23H23F3N2O4/c1-30-18-12-15(13-19(31-2)22(18)32-3)8-9-21(29)27-10-11-28-17-7-5-4-6-16(17)14-20(28)23(24,25)26/h4-9,12-14H,10-11H2,1-3H3,(H,27,29)/b9-8+ Smiles: COC1C(=CC(=CC=1OC)/C=C/C(=O)NCCN1C2=CC=CC=C2C=C1C(F)(F)F)OC Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power. Shelf Life: 1.0 years |
| Description | TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. Systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely. TG6-10-1 shows low-nanomolar antagonist activity against EP2. |
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