CZC-25146

Overview
Catalog #	bs-6583c-10mg-solid
Product Name	CZC-25146
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 488.54 Formula: C22 H25 F N6 O4 S CAS Number: 1191911-26-8 InChi Key: XXHHOTZUJIXPJX-UHFFFAOYSA-N InChi: InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27) Smiles: COC1C=C(C=CC=1NC1N=C(NC2=CC=CC=C2NS(C)(=O)=O)C(F)=CN=1)N1CCOCC1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	CZC-25146 is a potent and selective LRRK2 inhibitor. Leucine-rich repeat kinase-2 (LRRK2) mutations are the most important cause of familial Parkinson's disease. CZC-25146 prevents mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.