ABT-751

Overview
Catalog #	bs-6576c-10mg-solid
Product Name	ABT-751
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 371.41 Formula: C18 H17 N3 O4 S CAS Number: 141430-65-1 InChi Key: URCVCIZFVQDVPM-UHFFFAOYSA-N InChi: InChI=1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20) Smiles: COC1C=CC(=CC=1)S(=O)(=O)NC1=CC=CN=C1NC1C=CC(O)=CC=1 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	ABT-751, also known as E7010, is an orally bioavailable antimitotic sulfonamide. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.