SB216763

Overview
Catalog #	bs-6559c-10mg-solid
Product Name	SB216763
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 371.22 Formula: C19 H12 Cl2 N2 O2 CAS Number: 280744-09-4 InChi Key: JCSGFHVFHSKIJH-UHFFFAOYSA-N InChi: InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25) Smiles: CN1C=C(C2=C(C3C=CC(Cl)=CC=3Cl)C(=O)NC2=O)C2=CC=CC=C12 Purity: 98.0 Solubility: Soluble in DMSO, not in water Appearance: Solid Power Shelf Life: 1.0 years
Description	SB-216763 is a glycogen synthase kinase-3 (GSK3) inhibitor, which can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). SB-216763 is the first GSK3 inhibitor that can promote self-renewal of mESC co-cultured with MEFs for more than two months.