MGCD0103

Overview
Catalog #	bs-6555c-10mg-solid
Product Name	MGCD0103
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 396.44 Formula: C23 H20 N6 O CAS Number: 726169-73-9 InChi Key: HRNLUBSXIHFDHP-UHFFFAOYSA-N InChi: InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29) Smiles: NC1C=CC=CC=1NC(=O)C1C=CC(CNC2N=C(C=CN=2)C2=CC=CN=C2)=CC=1 Purity: 98.0 Solubility: DMSO: 13 mg/mL(32.79 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	MGCD0103, also known as Mocetinostat, is a rationally designed, orally available, Class 1-selective, small molecule, 2-aminobenzamide HDAC inhibitor with potential antineoplastic activity. MGCD0103 binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others.