TPI-1

Overview
Catalog #	bs-6547c-2mg-solid
Product Name	TPI-1
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 253.08 Formula: C12 H6 Cl2 O2 CAS Number: 79756-69-7 InChi Key: ZKHFYORNAYYOTM-UHFFFAOYSA-N InChi: InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H Smiles: O=C1C=CC(=O)C=C1C1C=C(Cl)C=CC=1Cl Purity: 98.0 Solubility: DMSO: 51 mg/mL(201.51 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.