BGJ-398

Overview
Catalog #	bs-6540c-2mg-solid
Product Name	BGJ-398
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 560.48 Formula: C26 H31 Cl2 N7 O3 CAS Number: 872511-34-7 InChi Key: QADPYRIHXKWUSV-UHFFFAOYSA-N InChi: InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) Smiles: CN(C(=O)NC1C(Cl)=C(C=C(OC)C=1Cl)OC)C1C=C(NC2C=CC(=CC=2)N2CCN(CC2)CC)N=CN=1 Purity: 98.0 Solubility: DMSO: 1 mg/mLwarmed(1.78 mM). Appearance: Solid Power Shelf Life: 1.0 years
Description	BGJ-398, also known as, Infigratinib or NVP-BGJ398, is a pan FGFR kinase inhibitor, and is an orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities. pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death.