IWR-1

Overview
Catalog #	bs-6528c-2mg-solid
Product Name	IWR-1
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 409.44 Formula: C25 H19 N3 O3 CAS Number: 1127442-82-3 InChi Key: ZGSXEXBYLJIOGF-ALFLXDJESA-N InChi: InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+ Smiles: O=C(NC1=CC=CC2=CC=CN=C21)C1C=CC(=CC=1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O Purity: 98.0 Solubility: DMSO : ≥ 46 mg/mL (112.35 mM) Appearance: Solid Power Shelf Life: 1.0 years
Description	IWR-1, also known as IWR-1-endo, is a an inhibitor of the Wnt signaling cascade through inhibiting TNKSs, binding only to the adenosine-binding site. IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression. IWR-1 inhibits cell proliferation and EMT even in the presence of TNF-α-induced cancer cell stimulation. IWR-1 also significantly suppressed cell migration, invasion, and matrix metalloproteinase activities of CRC cell lines. IWR-1 provides EMT reversal effects by directly suppressing survivin expression.