TUG-891

Overview
Catalog #	bs-6522c-2mg-solid
Product Name	TUG-891
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 364.41 Formula: C23 H21 F O3 CAS Number: 1374516-07-0 InChi Key: LPGBXHWIQNZEJB-UHFFFAOYSA-N InChi: InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26) Smiles: CC1C=CC(=CC=1)C1C=CC(F)=CC=1COC1C=CC(CCC(O)=O)=CC=1 Purity: 98.0 Solubility: DMSO : ≥ 180 mg/mL (493.95 mM) Appearance: Solid Power Shelf Life: 1.0 years
Description	TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.