ICRT-14

Overview
Catalog #	bs-6516c-2mg-solid
Product Name	ICRT-14
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 375.44 Formula: C21 H17 N3 O2 S CAS Number: 677331-12-3 InChi Key: NCSHZXNGQYSKLR-UNOMPAQXSA-N InChi: InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12- Smiles: CC1=C(C=C2SC(=O)N(C3C=CC=CC=3)C2=O)C=C(C)N1C1C=NC=CC=1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	ICRT-14 is a potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling in a reporter assay in vitro (IC50 = 40.3 nM). It inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) in quantitative reporter assays of β-catenin/Tcf4 binding (Ki = 53.51 μM).