RSL-3

Overview
Catalog #	bs-6495c-10mg-solid
Product Name	RSL-3
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 440.88 Formula: C23 H21 Cl N2 O5 CAS Number: 1219810-16-8 InChi Key: TXJZRSRTYPUYRW-NQIIRXRSSA-N InChi: InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10,18,21,25H,11-12H2,1-2H3/t18-,21+/m1/s1 Smiles: COC(=O)[C@H]1CC2=C(NC3=CC=CC=C32)[C@H](C2C=CC(=CC=2)C(=O)OC)N1C(=O)CCl Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	RSL-3 is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL-3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.