GSK-2981278

Overview
Catalog #	bs-6485c-2mg-solid
Product Name	GSK-2981278
Specifications
Storage Buffer	Powder
Storage Condition	Store in dry, dark place at -20C for 1 year.
Target
Product Information	Molecular Weight: 461.61 Formula: C25 H35 N O5 S CAS Number: 1474110-21-8 InChi Key: LZLBRISQTJVZNP-UHFFFAOYSA-N InChi: InChI=1S/C25H35NO5S/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3 Smiles: CC(C)CN(C1=CC=C(CC)C=C1)S(=O)(=O)C1=CC(CO)=C(C=C1)OCC1CCOCC1 Purity: 98.0 Solubility: Soluble in DMSO Appearance: Solid Power Shelf Life: 1.0 years
Description	GSK-2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). GSK-2981278 is a strong RORγ-selective inverse agonist that inhibits activation of the il17 promoter. GSK-2981278 robustly inhibits RORγ-mediated cytokine production at both the mRNA and protein level. GSK-2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK-2981278 will significantly limit Th17-type cytokine expression and should therefore lead to improved clinical outcomes for patients.